1016641-70-5

Usage

Uses

Used in Synthetic Chemistry:
4,4,5,5-Tetramethyl-2-(4-(methylsulfinyl)phenyl)-1,3,2-dioxaborolane is used as an intermediate for facilitating the synthesis of other complex organic molecules. Its unique structure allows it to participate in various chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Catalyst Applications:
In the field of catalysis, 4,4,5,5-Tetramethyl-2-(4-(methylsulfinyl)phenyl)-1,3,2-dioxaborolane is used as a catalyst to enhance the rate of chemical reactions. Its presence can lower the activation energy required for a reaction to proceed, thereby increasing the efficiency of the process. This makes it particularly useful in industrial applications where speed and yield are critical factors.

Upstream product

• 934-71-4 1-bromo-4-(methylsulfinyl)benzene 
• 73183-34-3 bis(pinacol)diborane 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 
• 190788-58-0 4,4,5,5-tetramethyl-2-(4-methylsulfanylphenyl)-[1,3,2]-dioxaborolane 

Downstream Products

• 1160270-24-5 ethyl 4-[4-(methylsulfinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoate 
• 1610373-34-6 5-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-(4-(methylsulfinyl)phenyl)picolinaldehyde 

Relevant academic research and scientific papers

Selective sulfoxidation of thioethers and thioaryl boranes with nitrate, promoted by a molybdenum-copper catalytic system

The catalytic reduction of nitrate by molybdo-enzymes plays a central role in the global biological cycle of nitrogen. However, the use of nitrates as oxidants in synthetic organic chemistry is very limited and typically requires very strong acidic and other extreme reaction conditions. We have developed a highly chemoselective and efficient catalytic process for the sulfoxidation of thioethers and arylthioethers containing boronic acid or boronic ester functional groups, using nitrate salts as oxidants. This homogeneous catalytic reaction was carried out in acetonitrile, where the MoO2Cl 2(OPPh3)2 complex 1 or a mixture of complex 1 with Cu(NO3)2 were used as catalysts. We examined the reaction mechanism using 1H, 15N, and 31P NMR techniques and 18O-labeled sodium nitrate (NaN18O 3) and show that the thioethers are oxidized by nitrate, generating nitrite. Our work adds to the existing chemical transformations available for organoboron compounds, providing straightforward accessibility to a variety of new substrates that could be suitable for Suzuki cross-coupling chemistry.

SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY

Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabe