101697-71-6

Basic information

• Product Name: Boc-Gly-Phe-OSu
• Synonyms: Boc-Gly-Phe-OSu
• CAS NO: 101697-71-6
• Molecular Weight: 419.434
• Mol File: 101697-71-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Boc-Gly-Phe-OSu(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Gly-Phe-OSu(101697-71-6)
• EPA Substance Registry System: Boc-Gly-Phe-OSu(101697-71-6)

Safety Data

• Hazardous Substances Data: 101697-71-6(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 4530-37-4 N-t-butyloxycarbonylglycyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 3392-07-2 tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate 

Downstream Products

• 713108-78-2 N-(tert-butoxycarbonyl)glycyl-N-(3-(imidazol-1-yl)propyl)-phenylalaninamide 
• 1025724-45-1 H-Gly-Phe-Met-OCH₂CH₂N(CH₂CH₃)2 trifluoroacetate 
• 1025724-52-0 Ac-Tyr(Ac)-Gly-Gly-Phe-Met-OCH₂CH₂N(CH₂CH₃)2 hydrochloride 

Relevant articles and documents

A new [2 + 1] mixed ligand concept based on [99(m)Tc(OH 2)3(CO)3]+: A basic study

Mixed ligand fac-tricarbonyl complexes of the general formula [M(L 1)(L2)(CO)3] (M = Re, 99(m)Tc, L1 = imidazole, benzyl isocyanide, L2 = 1H-imidazole-4-carboxylic acid, pyridine-2,4-dicarboxylic acid, pyridine-2,5-dicarboxylic acid) have been prepared starting from the precursors [M(OH2)3(CO)3]+. The complexes can be obtained in good yield and purity in a two-step procedure by first attaching the bidentate ligand followed by addition of the monodentate. 99mTc compounds can also be prepared at the tracer level in one-pot procedures with L1 and L2 being concomitantly present. This [2 + 1] approach allows the labeling of bioactive molecules containing a monodentate or a bidentate donor site. Examples given in here are N-(tert-butoxycarbonyl) glycyl-N-(3-(imidazol-1-yl)propyl)phenylalaninamide, 5-((3-(imidazol-1-yl) propyl)aminomethyl)-2′-deoxyuridine and 4-(5-isonitrilpentyl)-1-(2- methoxyphenyl)-piperazine as L1 and N-((6-carboxypyridine-3-yl) methyl)glycylphenyl-alanine as L2. The corresponding second ligand can be used to influence the physico-chemical properties of the conjugate. The crystal structures of [99Tc(OH2)(imc)(CO)3], [Re(OH2)(2,4-dipic)(CO)3], [Re(bic)(2,4-dipic)(CO) 3] and [Re(im)(2,5-dipic)(CO)3] are reported.

HIGH PENETRATION PRODRUG COMPOSITIONS OF PEPTIDES AND PEPTIDE-RELATED COMPOUNDS

The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of peptides and peptide-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.