1016980-41-8

Basic information

• Product Name: tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate;1-Boc-4-[3-(methoxycarbonyl)phenyl]piperidine
• CAS NO: 1016980-41-8
• Molecular Formula: C18H25NO4
• Molecular Weight: 319.401
• Mol File: 1016980-41-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate(1016980-41-8)
• EPA Substance Registry System: tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate(1016980-41-8)

Safety Data

• Hazardous Substances Data: 1016980-41-8(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate is a chemical compound used in organic synthesis and pharmaceutical research. It is a piperidine derivative with a tert-butyl ester group and a methoxycarbonyl functional group attached to the phenyl ring. tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate is commonly used as a building block in the synthesis of various pharmacologically active molecules, such as potential drug candidates or ligands for biological studies. Its unique structure and functional groups make it a versatile intermediate for creating diverse molecular structures, potentially leading to the discovery of new therapeutic agents or tools for studying biological processes.

Upstream product

• 744197-23-7 methyl 3-(piperidin-4-yl)benzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 766508-67-2 3-(piperidin-4-yl)benzoic acid 
• 618-89-3 methyl 3-bromobenzoate 
• 2905-65-9 methyl 3-chlorobenzoate 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 

Relevant articles and documents

Photoinduced Nickel-Catalyzed Deaminative Cross-Electrophile Coupling for C(sp2)-C(sp3) and C(sp3)-C(sp3) Bond Formation

The construction of C-C bonds through cross-coupling between two electrophiles in the absence of excess metallic reducing agents is a desirable objective in chemistry. Here, we show that N-alkylpyridinium salts can be efficiently merged with aryl or alkyl halides in an intermolecular fashion, affording products in up to 92% yield at ambient temperature. These reactions harness the ability of N-alkylpyridinium salts to form electron donor-acceptor complexes with Hantzsch esters, enabling photoinduced single-electron transfer and fragmentation to afford alkyl radicals that are subsequently trapped by a Ni-based catalytic species to promote C(sp2)-C(sp3) and C(sp3)-C(sp3) bond formation. The operationally simple protocol is applicable to site-selective cross-coupling and tolerates diverse functional groups, including those that are sensitive toward metal reductants.

TRIAZOLOPYRIDINE AND TRIAZOLOPYRIMIDINE INHIBITORS OF MYELOPEROXIDASE

The present invention provides compounds of Formula (I): wherein A and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.