1017238-08-2Relevant articles and documents
Formal total synthesis of neopeltolide
Vintonyak, Viktor V.,Maier, Martin E.
supporting information; experimental part, p. 1239 - 1242 (2009/04/12)
A concise synthesis of the core structure of the macrolide neopeltolide was develop featuring a Prins cyclization to fashion the pyran ring. Key steps in the synthesis of aldehyde 16 were a Leiqhton allylation and a Feringa-Minnaard asymmetric methyl cuprate addition to an unsaturated thioester. For lactonization, a classical Yamaguchin macrolactonization was used. The longest linear sequence consists of 17 steps providing lactone 26 with an overall yield of 23%.