101869-68-5Relevant articles and documents
Selective C-H bond hydroxylation of cyclohexanes in water by supramolecular control
Yang, Bin,Cui, Jian-Fang,Wong, Man Kin
, p. 30886 - 30893 (2017)
A new approach for selective hydroxylation of non-activated cyclohexanes using dioxirane generated in situ in water through supramolecular control has been developed. Using β-CD and γ-CD as the supramolecular hosts, selective hydroxylation of cyclohexane substrates, including trans/cis-1,4-, 1,3-and 1,2-dimethylcyclohexanes and trans/cis-decahydronaphthalene, was achieved in up to 54% yield in water. Furthermore, site-selective C-H bond hydroxylation of (+)-menthol was achieved by obstructing the approach of dioxirane to the C-H bond with higher steric hindrance through inclusion complexation with β-CD and γ-CD in water.
Cyclohexane-based 1,3-Dipodands; Complexation and Conformational Biasing
Shirodkar, Shailaja M.,Weisman, Gary R.
, p. 236 - 238 (1989)
Cyclohexane-based cis-1,3-dipodand (1) undergoes ring inversion to a diaxial conformation upon Na(1+) complexation, while related diaxially biased dipodand (2) is a better host.
