101883-50-5

Upstream product

• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 27613-27-0 3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile 
• 102595-29-9 1-hydroxy-3-phenyl-4-phenylazo-[2]naphthonitrile 
• 101439-64-9 (±)-1-hydroxy-3-phenyl-2-naphthonitrile 
• 451-40-1 phenyl benzyl ketone 
• 101439-68-3 1,4-dihydroxy-3-phenyl-[2]naphthonitrile 
• 101576-65-2 4-amino-1-hydroxy-3-phenyl-[2]naphthonitrile 

Relevant academic research and scientific papers

Synthesis of Vitamin K and Related Naphthoquinones via Demethoxycarbonylative Annulations and a Retro-Wittig Rearrangement

Anionic annulations of 3-nucleofugal phthalides with α-alkyl(aryl)acrylates involving a demethoxycarbonylation provide a succinct synthesis of vitamin K and related naphthoquinones. Also reported is a new cascade reaction stemming from a Cope-retro-Wittig rearrangement. This cascade leads to direct formation of 1-hydroxy-4-prenyloxynaphthalene-2-carboxylates from the corresponding α-prenyl acrylate acceptors.