1018899-99-4

Basic information

• Product Name: (R)-Fmoc-beta2-homoleucine
• Synonyms: (R)-Fmoc-beta2-homoleucine;(R)-FMoc-2-aMinoMethyl-4-Methyl-pentanoic acid;FMoc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid;(9H-Fluoren-9-yl)MethOxy]Carbonyl (R)-2-(Aminomethyl)-4-methylpentanoic acid
• CAS NO: 1018899-99-4
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.4382
• Mol File: 1018899-99-4.mol

Chemical Properties

• Melting Point: 134-135 °C
• Boiling Point: 572.1±33.0 °C(Predicted)
• Appearance: /
• Density: 1.188±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.45±0.21(Predicted)
• CAS DataBase Reference: (R)-Fmoc-beta2-homoleucine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Fmoc-beta2-homoleucine(1018899-99-4)
• EPA Substance Registry System: (R)-Fmoc-beta2-homoleucine(1018899-99-4)

Safety Data

• Hazardous Substances Data: 1018899-99-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 210345-89-4 (2R)-([amino]methyl)-4-methylpentanoic acid 
• 1415986-75-2 (4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one 
• 1119-16-0 isocaproic aldehyde 
• 113543-30-9 (S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one 
• 1415986-81-0 (2R)-2-(dibenzylamino)methyl-4-methylpentanoic acid 
• 1415986-78-5 S-ethyl (2R)-2-(dibenzylamino)methyl-4-methylpentanethioate 
• 501330-99-0 (4R)-isobutyl-2-((S)-1-phenylethyl)-isoxazolidin-5-one 
• 501330-86-5 2-acetyl-4-methyl-pentanoic acid benzyl ester 
• 118053-31-9 benzyl 4-methyl-2-methylenepentanoate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant articles and documents

Differential Effects of β3- versus β2-Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3-Derived α/β-Peptides

Oligomers containing α- and β-amino acid residues (α/β-peptides) have been shown to mimic the α-helical conformation of conventional peptides when the unnatural residues are derived from β3-amino acids or cyclic β-amino acids, but the impact of incorporating β2 residues has received little attention. The effects of β2 residues on the conformation and recognition behavior of α/β-peptides that mimic an isolated α-helix were investigated. This effort has focused on 26-mers based on the Bim BH3 domain; a set of isomers with identical α/β backbones that differ only in the placement of certain side chains along the backbone (β3 vs. β2 substitution) was compared. Circular dichroism data suggest that β2 residues can be helix-destabilizing relative to β3 residues, although the size of this effect seems to depend on side chain identity. Binding data show that β3→β2 substitution at sites that contact a partner protein, Bcl-xL, can influence affinity in a way that transcends effects on helicity.

Synthesis and biological evaluation of gramicidin S-inspired cyclic mixed α/β-peptides

Via a Mannich reaction involving a dibenzyliminium species and the titanium enolates of Evans' chiral acylated oxazolidinones the β2-amino acids (R)- and (S)-Fmoc-β2homovaline and (R)-Fmoc- β2homoleucine are synthesized. T

Enantioselective synthesis of beta-amino acids using hexahydrobenzoxazolidinones as chiral auxiliaries

A practical synthetic route for the asymmetric synthesis of β2-amino acids is described. In the first step, the procedure involves the N-acylation of readily available, enantiopure hexahydrobenzoxazolidinone (4R,5R)-1 with 3-methylbutanoyl chloride 2, 4-methylpentanoic acid 3, and 3-(1-tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid 4 to afford derivatives 5a, 5b, and 5c, respectively, which were alkylated with high diastereoselectivity by means of reaction between their sodium enolates and benzyl bromoacetate. Removal of the chiral auxiliary from the alkylated products followed by hydrogenation and hydrolysis gave β2-amino acids (S)-10a, (S)-10b, and (S)-10c, which were N-protected with Fmoc. Enantiomeric (R)-10a-c were similarly prepared from the isomeric hexahydrobenzoxazolidinone (4S,5S)-1; thus, the route presented here provides access to both enantiomers of valuable highly enantioenriched β2-amino acids.

Efficient synthesis of enantiomerically pure β2-amino acids via chiral isoxazolidinones

We report a practical and scalable synthetic route for the preparation of α-substituted β-amino acids (β2-amino acids). Michael addition of a chiral hydroxylamine, derived from α-methylbenzylamine, to an α-alkylacrylate followed by cyclization gives a diastereomeric mixture of α-substituted isoxazolidinones. These diastereomers are separable by column chromatography. Subsequent hydrogenation of the purified isoxazolidinones followed by Fmoc protection affords enantiomerically pure Fmoc-β2-amino acids, which are useful for β-peptide synthesis. This route provides access to both enantiomers of a protected β2-amino acid.

beta-peptides as catalysts: poly-beta-leucine as a catalyst for the Julia-Colonna asymmetric epoxidation of enones.

Poly-beta-leucines have been evaluated as catalysts for the Julia-Colonna asymmetric epoxidation of enones; the beta 3-isomer was found to be an effective catalyst for the epoxidation of chalcone (70% ee) and some analogues.