1018909-67-5Relevant articles and documents
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability
Lawton, Graham R.,Ranaivo, Hantamalala Ralay,Chico, Laura K.,Ji, Haitao,Xue, Fengtian,Martasek, Pavel,Roman, Linda J.,Martin Watterson,Silverman, Richard B.
experimental part, p. 2371 - 2380 (2009/09/05)
Overproduction of nitric oxide by neuronal nitric oxide synthase (nNOS) has been linked to several neurodegenerative diseases. We have recently designed potent and isoform selective inhibitors of nNOS, but the lead compound contains several basic function