393-77-1

Basic information

• Product Name: 2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOL
• Synonyms: 2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOL;4-HYDROXY-3,5-DINITROBENZOTRIFLUORIDE;ALPHA,ALPHA,ALPHA-TRIFLUORO-2,6-DINITRO-P-CRESOL;4-Hydroxy-3,5-dinitrobenzotrifluoride alpha,alpha,alpha-Trifluoro-2,6-dinitro-p-cresol;4-(Trifluoromethyl)-2,6-dinitrophenol
• CAS NO: 393-77-1
• Molecular Formula: C₇H₃F₃N₂O₅
• Molecular Weight: 252.1
• Mol File: 393-77-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 47 °C
• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.737
• Vapor Pressure: 0.052mmHg at 25°C
• Refractive Index: 1.549
• Solubility: soluble in Toluene
• CAS DataBase Reference: 2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOL(393-77-1)
• EPA Substance Registry System: 2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENOL(393-77-1)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 26-36/37/39
• RIDADR: 3224
• HazardClass: 6.1/4.1
• PackingGroup: I
• Hazardous Substances Data: 393-77-1(Hazardous Substances Data)

Usage

Uses

2,6-Dinitro-4-(trifluoromethyl)phenol is used in determination of Amino-containing compounds in pharmaceuticals by HPLC with pre-column derivatization.

InChI:InChI=1/C7H3F3N2O5/c8-7(9,10)3-1-4(11(14)15)6(13)5(2-3)12(16)17/h1-2,13H

Upstream product

• 393-75-9 4-chloro-3,5-dinitrobenzotrifluoride 
• 10223-72-0 N-n-butyl-2,6-dinitro-4-(trifluoromethyl)aniline 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 393-76-0 3,5-dinitro-4-fluorobenzotrifluoride 
• 2077-99-8 α,α,α-trifluoro-2,6-dinitro-N-propyl-p-toluidine 
• 1582-09-8 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzeneamine 
• 145323-41-7 N-(2,6-dinitro-4-trifluoromethylphenyl)sarcosine ethyl ester 
• 149-30-4 2-Mercaptobenzothiazole 
• 288-88-0 1,2,4-Triazole 
• 400-99-7 2-nitro-4-trifluoromethylphenol 

Downstream Products

• 1019-52-9 4-hydroxy-3,5-dinitrobenzoic acid 

Relevant articles and documents

The Stabilities of Meisenheimer Complexes. Part 41. Kinetic Studies of Adduct Formation and Nucleophilic Substitution in the Reactions of Hydroxide Ions with 1-X-3,5-Dinitrobenzenes and with 1-X-4-Chloro-3,5-dinitrobenzenes (X = H, CF3, CO2-) in Water-Dimethyl Sulphoxide Mixtures. T...

Kinetic and equilibrium measurements are compared for the reactions of (1) and (4) (X = CF3, CO2-, H) with hydroxide ions in dimethyl sulphoxide-water mixtures.The aducts (3), formed from (1), have higher thermodynamic stabilities than their isomers (2) although there is little kinetic discrimination in the rates of hydroxide attack at the three unsubstituted positions.The presence in (4) of the chlorine atom results in a general reduction in the rate of nucleophilic attack, the effect being particularly large for ipso-reaction (attack at the 4-position).Hence the reaction of (4) with base results in the initial formation of adducts (5).Contrary to a recent report the intermediates (6) on the reaction pathway to the phenols (7) are not sufficiently stable to allow spectrophotometric detection.

A simple synthesis of benzimidazole N-oxides from 2-nitroaniline derivatives - Scope and limitations

Several benzimidazole N-oxide derivatives were synthesized in very good yield by heating at reflux the corresponding N-alkyl-2-nitroaniline derivative with NaOH in 60% 1,4-dioxane-water. The effect of substituents on the aromatic ring and amino group on t

STUDIES ON FLUORINE CONTAINING HETEROCYCLIC COMPOUNDS: 4. REACTIONS OF 3-NITRO-4-CHLOROBENZOTRIFLUORIDE AND 3,5-DINITRO-4-CHLOROBENZOTRIFLUORIDE WITH FIVE MEMBERED HETEROCYCLES

The reactions of 3-nitro-4-chlorobenzotrifluoride (1a) and 3,5-dinitro-4-chlorobenzotrifluoride (1b) with heterocycles (2-5) are described.Six S-linked and N-substituted heterocycles (6, 9-11, 13), such as 2-(2-nitro-4-trifluoromethylphenylthio)benzothiazole (9a), were prepared from the reactions of 1a with benzotriazole (2), 2-mercaptobenzothiazole (5a) and 2-mercaptobenzoxazole (5b) and from the reactions of 1b with 2, 1,2,4-triazole (3) and 5a in DMF respectively. 1a reacted with 2-mercaptothiazoline (4) to give the desired product 7 and bis(2-nitro-4-trifluoromethylphenyl) thioether (8). 3-(2-Benzoxazolyl)-2-benzoxazolinethione (15) was obtained from the reaction of 1b with 5b.The spectral data and elemental analyses were fully in accord with the proposed structures, and the possible mechanisms for these compounds and other by-products were discussed.