101925-21-7Relevant articles and documents
First biological evaluation of developed 3-benzyloxyfluorenes as novel class of MDR modulators
Krug, Martin,Voigt, Burkhardt,Baumert, Christiane,Lüpken, Ralf,Molnár, Joséf,Hilgeroth, Andreas
experimental part, p. 2683 - 2688 (2010/07/09)
A series of 3-benzyloxy-1-aza-9-oxafluorenes has been synthesized and biologically evaluated as novel MDR modulators. The concentration dependent inhibition of the efflux pump ABCB1 (P-glycoprotein) has been characterized and is discussed in relation to calculated lipophilicity data. Instead of the molecular lipophilicity the exact positioning of functional groups was found decisive for the biological activities.
Synthesis of 4-Alkyl-3-pyridinols from 3-Benzyloxypyridine
Comins, Daniel L.,Stroud, Eric D.
, p. 1419 - 1420 (2007/10/02)
The addition of Grignard reagents to the 1-phenoxycarbonyl salt of 3-benzyloxypyridine and a catalytic amount of cuprous iodide afforded 4-alkyl-3-benzyloxy-1-phenoxycarbonyl-1,4-dihydropyridines in good yield.The crude dihydropyridines were aromatized wi