101925-26-2Relevant articles and documents
Iridium-catalyzed selective hydrogenation of 3-hydroxypyridinium salts: A facile synthesis of piperidin-3-ones
Huang, Wen-Xue,Wu, Bo,Gao, Xiang,Chen, Mu-Wang,Wang, Baomin,Zhou, Yong-Gui
supporting information, p. 1640 - 1643 (2015/04/14)
The selective hydrogenation of 3-hydroxypyridinium salts has been achieved using a homogeneous iridium catalyst, providing a direct access to 2- and 4-substituted piperidin-3-one derivatives with high yields, which are important organic synthetic intermediates and the prevalent structural motifs in pharmaceutical agents. Mild reaction conditions, high chemoselectivity, and easy scalability make this reaction highly practical for the synthesis of piperidin-3-ones.
Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis
Yoshida, Kazuhiro,Kawagoe, Fumihiro,Hayashi, Kazushi,Horiuchi, Shingo,Imamoto, Tsuneo,Yanagisawa, Akira
supporting information; experimental part, p. 515 - 518 (2009/07/10)
(Chemical Equation Presented) New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/ deprotection of nitrogen-containing dienes 4 are the key processes of the routes. An
Synthesis of 4-Alkyl-3-pyridinols from 3-Benzyloxypyridine
Comins, Daniel L.,Stroud, Eric D.
, p. 1419 - 1420 (2007/10/02)
The addition of Grignard reagents to the 1-phenoxycarbonyl salt of 3-benzyloxypyridine and a catalytic amount of cuprous iodide afforded 4-alkyl-3-benzyloxy-1-phenoxycarbonyl-1,4-dihydropyridines in good yield.The crude dihydropyridines were aromatized wi
