187030-98-4

Upstream product

• 626-60-8 3-Chloropyridine 
• 101925-15-9 3-Benzyloxy-4-phenyl-4H-pyridine-1-carboxylic acid phenyl ester 
• 101925-21-7 3-(benzyloxy)-4-phenylpyridine 
• 101925-26-2 4-Phenyl-3-pyridinol 
• 76509-17-6 3-benzyloxypyridine 
• 109-00-2 3-HYDROXYPYRIDINE 

Downstream Products

• 197590-75-3 (1S,5S,6R,R_S)-N-methyl-3-phenyl-6-(p-tolylsulfinyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 

Relevant academic research and scientific papers

Tropane derivatives and method for their synthesis

A compound of formula (I) wherein R1-R6have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of f

Dipolar cycloaddition route to diverse analogues of cocaine: The 6- and 7-substituted 3-phenyltropanes

In our quest for an antagonist or partial agonist of cocaine, access to certain 6- and 7-substituted 3-phenyltropanes of type I was required. Starting from 3-hydroxy-1-methyl-4-phenylpyridinium iodide, we disclose a pyridinium betaine-based dipolar cycloaddition route to tropenones of type II. In turn, we show how this intermediate can be transformed to type I products either through the copper-catalyzed conjugate addition reaction of Grignard reagents to the enones 7-9 or by the copper(I)-catalyzed cross coupling reaction of the allylic acetates 15a and 16a with Grignard reagents.