101975-16-0

Basic information

• Product Name: 1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone
• Synonyms: 1-[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]ethanone; ethanone, 1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-
• CAS NO: 101975-16-0
• Molecular Formula: C₁₀H₈F₄O₂
• Molecular Weight: 236.16
• EINECS: 600-260-0
• Mol File: 101975-16-0.mol

Chemical Properties

• Boiling Point: 234.9°C at 760 mmHg
• Flash Point: 93.2°C
• Density: 1.285g/cm³
• Vapor Pressure: 0.0517mmHg at 25°C
• Refractive Index: 1.437
• CAS DataBase Reference: 1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone(101975-16-0)
• EPA Substance Registry System: 1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone(101975-16-0)

Safety Data

• Hazardous Substances Data: 101975-16-0(Hazardous Substances Data)

Usage

Type of compound

Organofluorine compound

Usage

Building block in the synthesis of pharmaceuticals, agrochemicals, and materials science

Physical state

Colorless liquid

Odor

Slightly fruity

Solubility

Insoluble in water, soluble in organic solvents

Application

Intermediate in the production of other chemicals

Purity and stability

High purity and stability

Additional uses

Production of organic electronic materials, such as light-emitting diodes and organic transistors due to unique chemical properties

Upstream product

• 70126-48-6 3-(1',1',2',2'-tetrafluoroethoxy)-benzoic acid 
• 917-54-4 methyllithium 
• 1373866-56-8 N-methoxy-N-methyl-3-(1,1,2,2-tetrafluoroethoxy)benzamide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1083287-06-2 2-bromo-1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone 
• 957212-63-4 (E)-3-(2-bromo-6nitrophenyl)-1-[3-(1,1,2,2-tetrafluoroethoxy)-phenyl]-propenone 

Relevant articles and documents

TETRAZOLINONE COMPOUND AND USE THEREOF

The compound represented by formula (1): wherein R4 and R5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R7, R8, and R9 each represents a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group, or the like; R13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS

Compounds having the structure of Formula Ia, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.

Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors

2,3-Dihydro-3,8-diphenylbenzo[1,4]oxazines were identified as a new class of potent cholesteryl ester transfer protein inhibitors. The most potent compound 6a (IC50 = 26 nM) possessed a favorable pharmacokinetic profile with good oral bioavailability in rat (F = 53%) and long human liver microsome stability (t1/2 = 62 min). It increased HDL-C in human CETP transgenic mice and high-fat fed hamsters. The structure and activity relationship of this series will be described in this Letter.