70126-48-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(1,1,2,2-Tetrafluoroethoxy)benzoic acid is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure contributes to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(1,1,2,2-Tetrafluoroethoxy)benzoic acid serves as an intermediate for the production of compounds used in agricultural chemicals, aiding in the development of effective pest control and crop protection solutions.
Used in Specialty Chemicals Production:
3-(1,1,2,2-Tetrafluoroethoxy)benzoic acid is employed as a building block for the creation of liquid crystals, polymers, and other specialty chemicals. Its properties make it a valuable component in advancing the development of high-performance materials for diverse applications.
Used in Chemical Product Manufacturing:
Due to its high melting point and solubility in organic solvents, 3-(1,1,2,2-Tetrafluoroethoxy)benzoic acid is a crucial component in the manufacturing process of a variety of chemical products, enhancing their performance and functionality.

Upstream product

• 19438-10-9 methyl 3-hydroxybenzoate 
• 70126-45-3 3-(1,1,2,2-tetrafluoro-ethoxy)-benzoic acid methyl ester 

Downstream Products

• 76903-40-7 2-(m-1',1',2',2'-tetrafluoroethoxyphenyl)-3,1-benzoxazin-4-one 
• 70126-51-1 3-(1',1',2',2'-tetrafluoroethoxy)-benzoyl chloride 
• 1373866-56-8 N-methoxy-N-methyl-3-(1,1,2,2-tetrafluoroethoxy)benzamide 
• 1083287-06-2 2-bromo-1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone 
• 101975-16-0 1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]ethanone 
• 1404097-84-2 N-(4-formylbenzyl)-N-(1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)methanesulfonamide 
• 1404097-61-5 C₂₂H₂₂F₄N₂O₃ 
• 1404098-53-8 N-(1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide 
• 1404097-57-9 tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate 
• 1005786-48-0 N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-4-methoxyphenyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamide 
• 1005786-46-8 N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamide 
• 812699-81-3 N-[4-methyl-3-(4-pyrazin-2-yl-pyrimidin-2-ylamino)-phenyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamide 
• 114467-37-7 N,N'-Bis<3,3'-(1,1,2,2-tetrafluoroethoxy)benzoyl>hydrazine 
• 114467-47-9 2,5-Bis-<3,3'-(1,1,2,2-tetrafluoroethoxy)phenyl>-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Changes in the activity and selectivity of herbicides by selective fluorine substitution, taking bentranil and classic analogues as examples

The introduction of fluorine atoms into 2-phenyl-4H-3,1-benzoxazin-4-one (bentranil) led to sweeping changes in its herbicidal properties in some cases, and 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one ('fluorobentranil') was found to be the most active compound. It can be prepared from 2-amino-6-fluoro-benzoic acid or by direct halogen exchange of 5-chloro-2-phenyl-4H-3,1-benzoxazin-4-one. The latter reaction was investigated on a pilot scale, including a high-temperature (350°C) potassium fluoride halogen exchange without solvent. When sulfolane was used as a solvent, a side reaction at 220°C - partial decomposition to a diphenylether - could be prevented by addition of a small amount of a radical scavenger. Other intermediates with a pseudohalogen substitution were obtained by side-chain chlorination of suitable methylsulfanyl benzoic acid precursors and halogen exchange. 'Fluorobentranil' shows good broad-leaf activity and selectivity on rice, cereals and maize. In a second case study, the fluoro-substituted anthranilic acids mentioned above were also found to be appropriate for synthesizing herbicidal sulfonylurea (SU) compounds via Meerwein reaction of their aniline function. Methyl 2-[({[(4-chloro-6-methoxy-2- pyrimidinyl)-amino]carbonyl}amino)sulfonyl]-6-fluorobenzoate is an example of a SU that is compatible with maize, whereas the unsubstituted Classic analogue is not selective.