1019849-88-7Relevant articles and documents
One-pot three-component sysnthesis of α-iminonitriles by IBX/TBAB-mediated oxidative strecker reaction
Fontaine, Patrice,Chiaroni, Angle,Masson, Geraldine,Zhu, Jieping
supporting information; experimental part, p. 1509 - 1512 (2009/04/10)
The reaction of aldehydes, amines, and TMSCN in the presence of 2-iodoxybenzoic acid (IBX) and tetrabutylammonium bromide (TBAB) afforded α-iminonitriles in good to excellent yields under mild conditions. The presence of TBAB is essential for this transformation. The methodology was applied to a two-step synthesis of indolizidine via a microwave-assisted intramolecular cycloaddition of α-iminonitrile.