101997-42-6Relevant articles and documents
Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer's disease
Wang, Keren,Shi, Jian,Zhou, Yi,He, Ying,Mi, Jing,Yang, Jing,Liu, Shuang,Tang, Xiangcheng,Liu, Wenmin,Tan, Zhenghuai,Sang, Zhipei
, (2021/05/03)
Herein, combining 1,2,3,4-tetrahydroisoquinoline and benzylpiperidine groups into cinnamic acid derivatives, a series of novel cinnamic acid hybrids was rationally designed, synthesized and evaluated by the multi-target-directed ligands (MTDLs) strategy.
CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N′- diphenylureas
Imamura, Shinichi,Kurasawa, Osamu,Nara, Yoshi,Ichikawa, Takashi,Nishikawa, Youichi,Iida, Takehiro,Hashiguchi, Shohei,Kanzaki, Naoyuki,Iizawa, Yuji,Baba, Masanori,Sugihara, Yoshihiro
, p. 2295 - 2306 (2007/10/03)
We have previously reported the novel lead compound 1a as a CCR5 antagonist for treatment of HIV-1 infection. SAR studies on incorporating various acyl groups as a replacement for the 5-oxopyrrolidine-3-carbonyl group of the lead structure resulted in the