1020002-96-3

Upstream product

• 1019652-03-9 (2S)-2-(2-bromo-5-methoxy-phenyl)-1-(4-methoxy-phenyl)-ethanol 
• 139016-12-9 2,3-dihydro-2-(4′-methoxyphenyl)-5-methoxybenzofuran 
• 935-50-2 4,4-dimethoxycyclohexa-2,5-dienone 
• 150-76-5 4-methoxy-phenol 
• 19803-11-3 6-methoxy-2-(4-methoxyphenyl)benzofuran 
• 1198340-26-9 (E)-1-((1,2-dichlorovinyl)oxy)-4-methoxybenzene 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant academic research and scientific papers

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

A manganese-catalyzed oxidative kinetic resolution of cyclic benzylic ethers through asymmetric C(sp3)?H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the α position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.

Highly asymmetric synthesis of (+)-corsifuran A. Elucidation of the electronic requirements in the Ruthenium-NHC catalyzed hydrogenation of benzofurans

A short and efficient synthesis of ent-corsifuran A by a highly asymmetric hydrogenation of a benzofuran precursor is reported. In addition, the electronic influence of the substituents on the asymmetric hydrogenation of benzofurans is provided. Whereas the hydrogenation of electron-deficient benzofurans was achieved under very mild conditions, the presence of electron-donating groups in the benzofuran required harsher reaction conditions for achieving full conversion to the 2,3-dihydrobenzofuran.

Asymmetric synthesis of corsifuran A by an enantioselective oxazaborolidine reduction

(Chemical Equation Presented) Corsifuran A has been prepared in an enantiomerically pure form for the first time by an asymmetric reduction procedure, allowing confirmation of the absolute stereochemistry of the natural product as (R).