1020153-63-2

Usage

Uses

Used in Organic Synthesis:
1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is used as a key intermediate in organic synthesis for the creation of various complex molecules. Its unique structure allows for versatile reactions and functional group manipulations, making it a valuable component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is used as a building block for the development of new drugs. Its structural diversity and reactivity contribute to the design and synthesis of novel therapeutic agents with potential applications in treating various medical conditions.
Used in Agrochemicals:
1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is also utilized in the agrochemical sector as a starting material for the synthesis of pesticides and other agricultural chemicals. Its properties enable the creation of compounds that can effectively control pests and diseases in the agricultural industry.
Used in Material Science:
In the field of material science, 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is employed in the development of new materials with specific properties. Its incorporation into polymers and other materials can lead to enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Safety Precautions:
It is crucial to handle 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene with care, as it is both flammable and potentially hazardous if not managed properly. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be taken to minimize risks during its use and storage.

Upstream product

• 208183-93-1 3-(2-fluorophenyl)-prop-2-yn-1-ol 
• 348-52-7 1-Fluoro-2-iodobenzene 

Relevant academic research and scientific papers

Tricyclic Triazoles as σ1Receptor Antagonists for Treating Pain

The synthesis and pharmacological activity of a new series of 5a,7,8,8a-tetrahydro-4H,6H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine derivatives as potent sigma-1 receptor (σ1R) ligands are reported. A lead optimization program aimed at improving the aqueous solubility of parent racemic nonpolar derivatives led to the identification of several σ1R antagonists with a good absorption, distribution, metabolism, and excretion in vitro profile, no off-target affinities, and characterized by a low basic pKa (around 5) that correlates with high exposure levels in rodents. Two compounds displaying a differential brain-to-plasma ratio distribution profile, 12lR and 12qS, exhibited a good analgesic profile and were selected as preclinical candidates for the treatment of pain.

Synthesis and antiviral activity of novel spirocyclic nucleosides

The synthesis of a number of spirocyclic ribonucleosides containing either a triazolic or azetidinic system is described, along with two analogous phosphonate derivatives of the former. These systems were constructed from the same β-d-psicofuranose starti

Synthesis of Carbolines via Palladium/Carboxylic Acid Joint Catalysis

The combination of a Pd(0) complex with benzoic acid converts propargylic tryptamines to the corresponding tetrahydro-β-carbolines. The method uses unprotected indoles and affords the desired products with ample functional group tolerance. Detailed modeling studies reveal a close synergy between the organic and metal catalysts, which enables sequential alkyne isomerization, indole C-H activation, and eventual C-C reductive elimination to afford the target heterocycles.

Synthesis and antiviral properties of spirocyclic [1,2,3]-Triazolooxazine nucleosides

An efficient synthesis of spirocyclic triazolooxazine nucleosides is described. This was achieved by the conversion of β-D-psicofuranose to the corresponding azido-derivative, followed by alkylation of the primary alcohol with a range of propargyl bromide

Tricyclic triazolic compounds

The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of

Intramolecular azide-Alkyne for the fast assembly of structurally diverse, tricyclic 1,2,3-triazoles

The synthesis of novel tricyclic 1,2,3-triazoles starting from cyclic epoxides via the sequential azidolysis, propargylation and 1,3-dipolar cycloaddition is described. Derivatization by N-arylation reaction and the synthesis of enantiomerically pure comp