208183-93-1

Basic information

• Product Name: 2-Propyn-1-ol, 3-(2-fluorophenyl)- (9CI)
• Synonyms: 2-Propyn-1-ol, 3-(2-fluorophenyl)- (9CI);3-(2-Fluorophenyl)-2-propyn-1-ol
• CAS NO: 208183-93-1
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.1496832
• Product Categories: HALIDE
• Mol File: 208183-93-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 244.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• PKA: 13.02±0.10(Predicted)
• CAS DataBase Reference: 2-Propyn-1-ol, 3-(2-fluorophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-ol, 3-(2-fluorophenyl)- (9CI)(208183-93-1)
• EPA Substance Registry System: 2-Propyn-1-ol, 3-(2-fluorophenyl)- (9CI)(208183-93-1)

Safety Data

• Hazardous Substances Data: 208183-93-1(Hazardous Substances Data)

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 107-19-7 propargyl alcohol 

Downstream Products

• 406687-57-8 3-(2-fluorophenyl)propiolaldehyde 
• 1020153-63-2 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene 
• 769093-46-1 O-[3-(2-Fluoro-phenyl)-prop-2-ynyl]-hydroxylamine 

Relevant articles and documents

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Copper-Catalyzed Cross-Nucleophile Coupling of β-Allenyl Silanes with Tertiary C-H Bonds: A Radical Approach to Branched 1,3-Dienes

Described herein is a distinctive approach to branched 1,3-dienes through oxidative coupling of two nucleophilic substrates, β-allenyl silanes, and hydrocarbons appending latent functionality by copper catalysis. Notably, C(sp3)-H dienylation proceeded in a regiospecific manner, even in the presence of competitive C-H bonds that are capable of occurring hydrogen atom transfer process, such as those located at benzylic and other tertiary sites, or adjacent to an oxygen atom. Control experiments support the intermediacy of functionalized alkyl radicals.

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.