102028-50-2Relevant academic research and scientific papers
Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity
Manfredini, Stefano,Pavan, Barbara,Vertuani, Silvia,Scaglianti, Martina,Compagnone, Donatello,Biondi, Carla,Scatturin, Angelo,Tanganelli, Sergio,Ferraro, Luca,Prasad, Puttur,Dalpiaz, Alessandro
, p. 559 - 562 (2002)
To improve the entry of certain drugs into brain, ascorbic acid (AA) conjugates of these drugs were synthesized and their capacity to interact with SVCT2 ascorbate transporters was explored. Kinetic studies clearly indicate that all of the conjugates were
Photoreductive Removal of O-Benzyl Groups from Oxyarene N-Heterocycles Assisted by O-Pyridine-pyridone Tautomerism
Todorov, Aleksandar R.,Wirtanen, Tom,Helaja, Juho
, p. 13756 - 13767 (2017/12/26)
Facile photoreductive protocols have been developed to remove benzyl O-protective groups from oxyarene N-heterocycles at positions capable for 2-/4-O-pyridine-2-/4-pyridone tautomerism. Blue light irradiation, a [Ru] or [Ir] photocatalyst, and ascorbic acid in a water-acetonitrile solution debenzylates a variety of aryl N-heterocycles cleanly and selectively. Ascorbic acid has two functions in the reaction. On the one hand, it protonates the N-heterocycles that reduces their reduction potentials notably and on the other hand it acts as a sacrificial reductant. Reduction potentials and free energy barriers calculated at the CPCM-B3LYP/6-31+G? level can predict the reactivities of the studied substrates.
Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules
Manfredini, Stefano,Vertuani, Silvia,Pavan, Barbara,Vitali, Federica,Scaglianti, Martina,Bortolotti, Fabrizio,Biondi, Carla,Scatturin, Angelo,Prasad, Puttur,Dalpiaz, Alessandro
, p. 5453 - 5463 (2007/10/03)
Preliminary investigations allowed us to anticipate that conjugation of nipecotic acid with l-ascorbate (AA) gave a prodrug endowed with anticonvulsant activity in mice. In view of these results, and in order to get deepen insight into the molecular aspec
