102035-35-8Relevant academic research and scientific papers
LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
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Paragraph 0446, (2013/03/26)
Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
CONTROLLING BENZYLIC FUNCTIONALITY AND STEREOCHEMISTRY: 2. SYNTHESIS OF THE PSEUDOPTEROSIN AGLYCONE
McCombie, Stuart W.,Cox, Brian,Ganguly, Ashit K.
, p. 2087 - 2090 (2007/10/02)
Homologation, cyclisation, and reduction converted the tetralin (2) to the hexahydrophenalenol (8), which was methylated to afford (19) via alkoxide-directed metallation.The degree of stereoselectivity resulting from reactions of (19) and congeners with allylsilane - Lewis acid combinations was markedly dependent upon substitution patterns, whereas Et2AlCN-SnCl4 produced pseudoaxial nitriles.The trimethyl nitrile (24) was elaborated to the pseudopterosin aglycone (4).
Benzylic Cyanation via Oxidation and Simultaneous Nucleophilic Substitution
Lemaire, Marc,Doussot, Joel,Guy, Alain
, p. 1581 - 1584 (2007/10/02)
Use of dichlorodicyano benzoquinone and trimethylsilyl cyanide in suitable solvent permits the direct and ready transformation of benzylic C-H bonds to C-CN bonds with high yield and selectivity via oxidation and simultaneous nucleophilic substitution.
