113967-27-4Relevant academic research and scientific papers
AMINOTRIAZOLE IMMUNOMODULATORS FOR TREATING AUTOIMMUNE DISEASES
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, (2017/08/07)
1-Acyl-3-(heteroaryl)-1H-1,2,4-triazol-5-amines of formula (I) are disclosed. These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.
LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
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Paragraph 0447, (2013/03/26)
Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
Asymmetric pericyclic cascade approach to spirocyclic oxindoles
Richmond, Edward,Duguet, Nicolas,Slawin, Alexandra M. Z.,Lebl, Tomas,Smith, Andrew D.
supporting information; experimental part, p. 2762 - 2765 (2012/07/14)
The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.
Lewis Acid-Promoted Favorskii-Type Ring Contraction of Some Cyclic α-Bromo Ketones and Their Acetals
Maiti, Swaraj B.,Ray Chaudhuri, S. R.,Chatterjee, Amareshwar
, p. 806 - 809 (2007/10/02)
The α-bromo cycloalkyl aryl ketones 2a-d on heating with zinc chloride in methanol furnished in moderate to good yields the ring-contracted products 3a-d having gem methyl carbomethoxy function.The acetals of the related α-bromo ketones 7a-c, lacking the methyl group on the halogen-bearing carbon atom, afforded in acceptable yields the ring-contracted esters 8a-c when heated in protic solvent.The limitation of the present ring-contraction procedure has been discussed.
