T:Toxic;102040-01-7Relevant articles and documents
Synthesis and antimicrobial activity of benzazolyl azolyl urea derivatives
Narendra babu, Kayathi,Nagarjuna, Ummadi,Reddy, Guda Dinneswara,Padmaja, Adivireddy,Padmavathi, Venkatapuram
, (2019)
A new class of benzazolyl azolyl urea derivatives were prepared by the reaction of methyl benzazoyl carbamates with azolyl amines in the presence of mild base potassium tert-butoxide. The presence of electron withdrawing substituents on the aromatic ring enhanced the activity. Nitro substituted benzothiazolyl thiazolyl urea, benzothiazolyl imidazolyl urea and benzimidazolyl thiazolyl urea exhibited potential antibacterial activity against Bacillus subtilis. The compound benzothiazolyl imidazolyl urea and nitro substituted benzimidazolyl imidazolyl urea showed potential antifungal activity against Aspergillus niger.
Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.
Valdez, Juan,Cedillo, Roberto,Hernandez-Campos, Alicia,Yepez, Lilian,Hernandez-Luis, Francisco,Navarrete-Vazquez, Gabriel,Tapia, Amparo,Cortes, Rafael,Hernandez, Manuel,Castillo, Rafael
, p. 2221 - 2224 (2002)
Compounds 1-18 have been synthesized and tested in vitro against the protozoa Giardia lamblia, Entamoeba histolytica and the helminth Trichinella spiralis. Inhibition of rat brain tubulin polymerization was also measured and compared for each compound. Results indicate that most of the compounds tested were more active as antiprotozoal agents than Metronidazole and Albendazole. None of the compounds was as active as Albendazole against T. spiralis. Although only compounds 3, 9 and 15 (2-methoxycarbonylamino derivatives) inhibited tubulin polymerization, these were not the most potent antiparasitic compounds.
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Fuchs et al.
, p. 191,193, 194, 196 (1972)
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Carbendazim preparation technology
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Paragraph 0007; 0015, (2017/01/17)
The invention discloses a carbendazim preparation method. Being improved based on a traditional synthesis technology, the carbendazim preparation method is characterized in that firstly, a methylbenzene and water biphasic solvent reaction system is adopted, so that carbendazim appearance is improved, carbendazim is bright white, purity can be above 99.8% and carbendazim grade is increased; secondly, a method that concentrated hydrochloric acid and a methyl cyanocarbamate cyclizing agent are added dropwise simultaneously is adopted, and carbendazim yield can be above 97.5%. Compared with an existing traditional synthesis technology, the carbendazim preparation method has the greatest advantages that carbendazim yield is high, and the carbendazim is excellent in color and luster and high in purity, thereby being a method capable of preparing the high-quality carbendazim.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H- benzo[d]imidazol-2-yl carbamate derivatives
Liu, Xuefei,Chen, Qianqian,Zhu, Ju,Fan, Yongzheng,Ding, Lili,Zhao, Juntao,Han, Guangqian,Tian, Wei,Qi, Jingjing,Zhou, Youjun,Lv, Jiaguo
scheme or table, p. 3554 - 3559 (2012/06/18)
A series of novel methyl 5-substituted 1H-benzo[d]imidazol-2-ylcarbamates were designed, synthesized, and their acrosin inhibitory activities evaluated in vitro. The results of acrosin inhibitory activity showed that all title compounds were more potent than the control TLCK. Compound 4w displayed the most potent acrosin inhibitory activity among all the compounds, with an IC 50 of 6.3 × 10-5 M. The studies provide a new structural class for the development of novel acrosin inhibitory agents.
