1020575-89-6

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(5-Bromo-2-nitro-phenyl)-ethanol is used as a chiral building block for the synthesis of pharmaceuticals. Its unique structure allows for the creation of chiral ligands, catalysts, and potential drug candidates, making it a valuable component in the development of new medications.
Used in Organic Compound Synthesis:
In the field of organic chemistry, 1-(5-Bromo-2-nitro-phenyl)-ethanol serves as a key component in the synthesis of various organic compounds. Its versatility in chemical reactions contributes to the development of a wide range of products.
Used in Medicine and Biotechnology:
1-(5-Bromo-2-nitro-phenyl)-ethanol is used as an antimicrobial and antifungal agent in the medical and biotechnology industries. Its ability to combat microorganisms and fungi makes it a potentially useful substance in the development of treatments for various infections and diseases.
Used in Research and Development:
This chemical compound is also utilized as a reagent in the preparation of bioactive molecules and pharmaceutical intermediates. Its involvement in research and development underscores its importance in advancing scientific knowledge and innovation within the pharmaceutical and biotechnology sectors.

Upstream product

• 20357-20-4 5-bromo-2-nitrobenzaldehyde 
• 75-24-1 trimethylaluminum 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 41877-24-1 1-(5-bromo-2-nitrophenyl)ethane-1-one 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 41877-24-1 1-(5-bromo-2-nitrophenyl)ethane-1-one 
• 1043450-13-0 (3-(1-hydroxyethyl)-4-nitrophenyl)(2-phenylquinolin-3-yl) methanone 

Relevant academic research and scientific papers

Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light

A new chromophore, 2-(4-nitrophenyl)benzofuran (NPBF), was designed for two-photon (TP) uncaging using near-IR light. The TP absorption (TPA) cross-sections of the newly designed NPBF chromophore were determined to be 18 GM at 720 nm and 54 GM at 740 nm in DMSO. The TP uncaging reaction of a caged benzoate with the NPBF chromophore quantitatively produced benzoic acid with an efficiency (δu) of ～5.0 GM at 740 nm. The TP fragmentation of an EGTA unit was observed with δu = 16 GM. This behavior makes the new chromophore a promising TP photoremovable protecting group for physiological studies.

Blue Light Activated Rapamycin for Optical Control of Protein Dimerization in Cells and Zebrafish Embryos

Rapamycin-induced dimerization of FKBP and FRB is the most commonly utilized chemically induced protein dimerization system. It has been extensively used to conditionally control protein localization, split-enzyme activity, and protein-protein interactions in general by simply fusing FKBP and FRB to proteins of interest. We have developed a new aminonitrobiphenylethyl caging group and applied it to the generation of a caged rapamycin analog that can be photoactivated using blue light. Importantly, the caged rapamycin analog shows minimal background activity with regard to protein dimerization and can be directly interfaced with a wide range of established (and often commercially available) FKBP/FRB systems. We have successfully demonstrated its applicability to the optical control of enzymatic function, protein stability, and protein subcellular localization. Further, we also showcased its applicability toward optical regulation of cell signaling, specifically mTOR signaling, in cells and aquatic embryos.

FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF

Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.

Calcium Uncaging with Visible Light

We have designed a nitroaromatic photochemical protecting group that absorbs visible light in the violet-blue range. The chromophore is a dinitro derivative of bisstyrylthiophene (or BIST) that absorbs light very effectively (ε440 = 66,000 M-1 cm-1 and two-photon cross section of 350 GM at 775 nm). We developed a "caged calcium" molecule by conjugation of BIST to a Ca2+ chelator that upon laser flash photolysis rapidly releases Ca2+ in 2+, was delivered into acutely isolated mouse cardiac myocytes, where either one- and two-photon uncaging of Ca2+ induced highly local or cell-wide physiological Ca2+ signaling events.

Photolabile compound and substrate for oligomer probe array with the same

Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.

Photolabile compound, oligomer probe array and substrate for oligomer probe array containing the same, and manufacturing method of the same

A photolabile compound, an oligomer probe array, and a susbtrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed. wherein, X is or R1 is hydrogen, an alkyl group, or an acetyl group, R2 is hydrogen, methyl, ethyl, propyl, or phenyl.

PHOTOLABILE COMPOUND, OLIGOMER PROBE ARRAY AND SUBSTRATE FOR OLIGOMER PROBE ARRAY CONTAINING THE SAME, AND MANUFACTURING METHOD OF THE SAME

A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.