1020609-33-9Relevant academic research and scientific papers
Cobalt-catalyzed asymmetric cyclopropanation with diazosulfones: Rigidification and polarization of ligand chiral environment via hydrogen bonding and cyclization
Zhu, Shifa,Ruppel, Joshua V.,Lu, Hongjian,Wojtas, Lukasz,Zhang, X. Peter
, p. 5042 - 5043 (2008)
A new D2-symmetric chiral porphyrin P6 (2,6-DiMeO-ZhuPhyrin) with enhanced chiral rigidity and polarity was designed and synthesized through incorporation of hydrogen bonding and cyclic structure. Its cobalt(II) complex [Co(P6)] is a highly active and selective catalyst for asymmetric cyclopropanation of alkenes with diazosulfones. The [Co(P6)]-based catalytic system is suitable for various aromatic olefins as well as electron-deficient olefins, including α,β-unsaturated esters, ketones, and nitriles, forming the corresponding cyclopropyl sulfones under mild conditions in high yields and high selectivities. In most cases, both excellent diastereo- and enantioselectivities were achieved. Copyright
COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION WITH DIAZOSULFONES
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Page/Page column 49; 50, (2009/10/22)
Asymmetric cyclopropanation of olefins with diazosulfones.
