1020719-18-9

Basic information

• Product Name: N-2-Benzyloxyphenyl α-Benzilidene-d5 Isobutyrylacetamide
• Synonyms: N-2-Benzyloxyphenyl α-Benzilidene-d5 Isobutyrylacetamide;4-Methyl-3-oxo-N-[2-(phenylMethoxy)phenyl]-2-(phenylMethylene)pentanaMide-d5;4-Methyl-3-oxo-N-[2-(phenylmethoxy)phenyl]-2-(phenyl-2,3,4,5,6-d5-methylene)pentanamide
• CAS NO: 1020719-18-9
• Molecular Formula: C₂₆H₂₅NO₃
• Molecular Weight: 399.4816
• Product Categories: Various Intermediates;Intermediates;Isotope Labelled Compounds;Intermediates, Isotope Labelled Compounds
• Mol File: 1020719-18-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: N-2-Benzyloxyphenyl α-Benzilidene-d5 Isobutyrylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-Benzyloxyphenyl α-Benzilidene-d5 Isobutyrylacetamide(1020719-18-9)
• EPA Substance Registry System: N-2-Benzyloxyphenyl α-Benzilidene-d5 Isobutyrylacetamide(1020719-18-9)

Safety Data

• Hazardous Substances Data: 1020719-18-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

A deuterated intermediate of the metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Upstream product

• 4560-41-2 2-benzyloxynitrobenzene 
• 20012-63-9 o-(benzyloxy)aniline 
• 14132-51-5 2,3,4,5,6-pentadeuteriobenzaldehyde 
• 265989-31-9 N-(2-(benzyloxy)phenyl)-4-methyl-3-oxopentanamide 

Downstream Products

• 265989-41-1 C₄₇H₄₈⁽²⁾H₅FN₂O₆ 
• 265989-42-2 C₄₀H₄₂⁽²⁾H₅FN₂O₆ 
• 777841-55-1 C₃₃H₃₀⁽²⁾H₅FN₂O₆ 
• 265989-50-2 C₃₃H₂₈⁽²⁾H₅FN₂O₅ 

Relevant articles and documents

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.