265989-50-2 Usage
Uses
Used in Pharmaceutical Industry:
2-Hydroxy Atorvastatin Lactone-d5 is used as a therapeutic agent for the treatment of hypercholesterolemia. It functions by lowering elevated LDL-cholesterol and triglyceride levels in patients, thus helping to manage and reduce the risk of cardiovascular diseases.
Used in Research and Development:
2-Hydroxy Atorvastatin Lactone-d5 is also utilized as a research tool in the development of new drugs and therapies related to cholesterol management and cardiovascular health. Its isotopically labeled nature allows for easier tracking and analysis in various experimental settings, contributing to a better understanding of the underlying mechanisms and potential improvements in treatment strategies.
Used in Drug Metabolism Studies:
Furthermore, 2-Hydroxy Atorvastatin Lactone-d5 serves as a valuable compound in studying the metabolism and pharmacokinetics of Atorvastatin. This helps researchers to optimize drug dosages, understand the metabolic pathways, and identify potential drug-drug interactions, ultimately leading to safer and more effective treatments for patients with hypercholesterolemia.
Check Digit Verification of cas no
The CAS Registry Mumber 265989-50-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,5,9,8 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 265989-50:
(8*2)+(7*6)+(6*5)+(5*9)+(4*8)+(3*9)+(2*5)+(1*0)=202
202 % 10 = 2
So 265989-50-2 is a valid CAS Registry Number.
265989-50-2Relevant academic research and scientific papers
Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum
Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed
, p. 261 - 270 (2007/10/03)
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
