1020719-43-0 Usage
Uses
Used in Pharmaceutical Industry:
2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-D5-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide is used as an intermediate compound for the synthesis of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is specifically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia, making this intermediate compound crucial for the development and production of an essential medication in the treatment of cardiovascular diseases.
Chemical Properties:
2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-D5-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide exhibits the properties of a light yellow foamy solid, which may influence its handling and processing in the pharmaceutical industry. Its chemical structure and properties contribute to its role as a key intermediate in the synthesis of Atorvastin, highlighting its importance in the development of effective treatments for hypercholesterolemia.
Check Digit Verification of cas no
The CAS Registry Mumber 1020719-43-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,0,7,1 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1020719-43:
(9*1)+(8*0)+(7*2)+(6*0)+(5*7)+(4*1)+(3*9)+(2*4)+(1*3)=100
100 % 10 = 0
So 1020719-43-0 is a valid CAS Registry Number.
1020719-43-0Relevant academic research and scientific papers
Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum
Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed
, p. 261 - 270 (2007/10/03)
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
