102098-31-7

Basic information

• Product Name: 2-(N-Benzyl-N-methylamino)-ethyl 4-(2-difluoromethoxyphenyl)-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydropyridine-3-carboxylate
• CAS NO: 102098-31-7
• Molecular Weight: 590.604
• Mol File: 102098-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(N-Benzyl-N-methylamino)-ethyl 4-(2-difluoromethoxyphenyl)-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-Benzyl-N-methylamino)-ethyl 4-(2-difluoromethoxyphenyl)-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydropyridine-3-carboxylate(102098-31-7)
• EPA Substance Registry System: 2-(N-Benzyl-N-methylamino)-ethyl 4-(2-difluoromethoxyphenyl)-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydropyridine-3-carboxylate(102098-31-7)

Safety Data

• Hazardous Substances Data: 102098-31-7(Hazardous Substances Data)

Upstream product

• 54527-73-0 2-(N-benzyl-N-methylamino)-ethyl 3-aminocrotonate 
• 115578-89-7 5,5-dimethyl-2-[1-(2-difluoromethoxybenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 111011-80-4 2-acetonyl-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinane 
• 1005-69-2 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 54527-73-0 2-ethyl 3-aminocrotonate 
• 146139-63-1 2-<1-acetyl-2-(2-difluoromethoxyphenyl)ethenyl>-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinane 

Relevant articles and documents

Synthesis of 1,4-dihydropyridine-5-phosphonates and their calcium-antagonistic and antihypertensive activities

The effect of the 3-carboxylic-ester variation in 2,2-dimethyltrimethylene 3-alkoxycarbonyl-4-aryl-1,4-dihydro-2,6-dimethyl-5-pyridinephosphonate s (1) was investigated with relation to the calcium-antagonistic and antihypertensive activities: the analogs containing the alkyl groups of not more than 12 carbons and an amino functionality in the carboxylic-ester moiety were synthesized to be examined for biological activities. Among them, 2-[benzyl(phenyl)amino]-ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-di methyl-4-(3-nitrophenyl)-3-pyridine-carboxylate hydrochloride ethanol (NZ-105) showed particularly beneficial activities and was selected for further pharmacological studies and clinical development. Some aspects of the structure-activity relationships and solid-state structure of NZ-105 by X-ray crystallographic analysis were described.

Synthesis and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. II

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