102108-01-0Relevant academic research and scientific papers
Pyridine-N-oxide as a mild reoxidant which transforms osmium-catalyzed oxidative cyclization
Donohoe, Timothy J.,Wheelhouse, Katherine M. P.,Lindsay-Scott, Peter J.,Glossop, Paul A.,Nash, Ian A.,Parker, Jeremy S.
, p. 2872 - 2875 (2008/12/23)
(Chemical Equation Presented) The PNOman can: The use of pyridine-N-oxide (PNO) transforms the catalytic oxidative cyclization to include the formation of pyrrolidines from N-Z-protected amino alcohols and amino acids (see scheme; Z = PhCH2OCO). This new method expands the scope of the oxidative cyclization as illustrated with the synthesis of a range of di- and trisubstituted pyrrolidines with complete control of stereochemistry.
