1021372-74-6

Basic information

• Product Name: 1-(phenylsulfonyl)piperidin-3-ol
• Synonyms: 1-(phenylsulfonyl)piperidin-3-ol
• CAS NO: 1021372-74-6
• Molecular Weight: 241.311
• Mol File: 1021372-74-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(phenylsulfonyl)piperidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(phenylsulfonyl)piperidin-3-ol(1021372-74-6)
• EPA Substance Registry System: 1-(phenylsulfonyl)piperidin-3-ol(1021372-74-6)

Safety Data

• Hazardous Substances Data: 1021372-74-6(Hazardous Substances Data)

Upstream product

• 6859-99-0 3-hydroxypiperazine 
• 80-17-1 benzenesufonyl hydrazide 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 267666-10-4 N-benzenesulfonyl-3-piperidone 
• 1335288-20-4 C₁₅H₁₉NO₄S 

Relevant articles and documents

Metal-free synthesis of sulfonamides via iodine-catalyzed oxidative coupling of sulfonyl hydrazides and amines

A novel, rapid, and environmentally-friendly protocol for the synthesis of sulfonamides using iodine as catalyst under solvent-free conditions is described. This method involves the oxidative coupling of sulfonyl hydrazides and amines in the presence of catalytic amount of iodine using TBHP as oxidant. This protocol does not require purification techniques such as column chromatography and recrystalization.

Synthesis of 1,2,4-trisubstituted-1,2,5,6-tetrahydropyridines

A novel method for the synthesis of 1,2,4-trisubstituted- or 1,2,3,4-tetrasubstituted-1,2,5,6-tetrahydropyridine is presented. The process was carried out by the bromomethoxylation of 4-substituted-1,2,5,6- tetrahydropyridines 1 with N-bromosuccinimide (NBS) in methanol, dehydrobromination with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), and boron trifluoride etherate (BF3-OEt2)-catalyzed cross coupling of the corresponding enamine with trimethylsilyl-based nucleophiles. Homokainoid analogs were also synthesized via the protocol.