242474-65-3Relevant academic research and scientific papers
A simple and versatile route to novel conjugated β-enaminonitriles and their application for the highly regioselective synthesis of nicotinonitriles using a Vilsmeier-type reagent
Katritzky, Alan R.,Denisenko, Anna,Arend, Michael
, p. 6076 - 6079 (1999)
A straightforward synthesis of conjugated β-enaminonitriles from ketones and β-aminocrotononitrile mediated by TiCl4 is described. The reaction of these novel dienamines with a Vilsmeier-type reagent provides a mild and highly regioselective route for the preparation of nicotinonitriles.
The Vinylogous Mannich Reaction: An Efficient Access to Substituted Nicotinonitriles
Winter, Andreas,Risch, Nikolaus
, p. 1959 - 1964 (2007/10/03)
A straightforward method for the preparation of substituted nicotinonitriles has been developed. Starting from conjugated β-enaminonitriles and iminium salts, this methodology establishes a convenient access to 6-aryl- (5), 6-amino- (16) and 6-carboxylic ester-substituted derivatives 14 and as well to acetic acid-substituted pyrroles 12.
