1021539-50-3Relevant academic research and scientific papers
Discovery of selective glucocorticoid receptor modulator MK-5932
Bungard, Christopher J.,Hartman, George D.,Manikowski, Jesse J.,Perkins, James J.,Bai, Chang,Brandish, Philip E.,Euler, Danielle H.,Hershey, James C.,Schmidt, Azriel,Fang, Yulin,Norcross, Ryan T.,Rushmore, Tom H.,Thompson, Charles D.,Meissner, Robert S.
, p. 7374 - 7386 (2012/01/06)
A series of partial agonists of the Glucocorticoid Receptor were prepared targeting reduced transactivation activity, while maintaining significant transrepression activity. Incorporation of an ortho-aryl amide produced compounds with the desired in vitro
PROCESS FOR MAKING GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 21, (2009/05/30)
The invention encompasses a process for making 2-[1-phenyl-5-hydroxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives, which are glucocorticoid receptor ligands, useful for the treatment of inflammatory and immunological diseases.
2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 53, (2008/12/05)
The present invention is directed to 2- [l-phenyl-5 -hydroxy or methoxy-4alpha- methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives of formula I (I) as glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflamma
