102170-56-9

Basic information

• Product Name: 2-BROMO-6-METHYL-4-NITROANILINE
• Synonyms: 2-BROMO-6-METHYL-4-NITROANILINE;2-Methyl-4-nitro-6-bromoaniline;2-BROMO-6-METHYL-4-NITROANILINE 98%;2-Bromo-6-methyl-4-nitroaniline,98%;2-BroMo-6-Methyl-4-nitro-phenylaMine
• CAS NO: 102170-56-9
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.05
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Amines;C7;Nitrogen Compounds
• Mol File: 102170-56-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 180-184 °C
• Boiling Point: 366 °C at 760 mmHg
• Flash Point: 175.2 °C
• Appearance: yellow needles
• Density: 1.7207 (rough estimate)
• Vapor Pressure: 1.51E-05mmHg at 25°C
• Refractive Index: 1.5150 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -1.34±0.20(Predicted)
• CAS DataBase Reference: 2-BROMO-6-METHYL-4-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-METHYL-4-NITROANILINE(102170-56-9)
• EPA Substance Registry System: 2-BROMO-6-METHYL-4-NITROANILINE(102170-56-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37
• Safety Statements: 36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 102170-56-9(Hazardous Substances Data)

Usage

Chemical Properties

yellow needles

InChI:InChI=1/C7H7BrN2O2/c1-4-2-5(10(11)12)3-6(8)7(4)9/h2-3H,9H2,1H3

Upstream product

• 99-52-5 2-methyl-4-nitro-benzenamine 
• 10035-10-6 hydrogen bromide 
• 7722-84-1 dihydrogen peroxide 
• 139291-81-9 2-methyl-4-nitroaniline hydrochloride 

Downstream Products

• 175610-68-1 1-bromo-2-fluoro-3-methyl-5-nitro-benzene 
• 685109-10-8 7-bromo-5-nitro-1H-indazole 
• 603-78-1 2,3-dibromobenzoic acid 
• 1263376-30-2 3,4-dibromo-5-methyl-aniline 
• 61563-25-5 2,3-dibromotoluene 
• 98590-25-1 chloro-acetic acid-(2-bromo-6-methyl-4-nitro-anilide) 
• 73557-64-9 2,3-dibromo-5-nitro-toluene 
• 52488-28-5 1-bromo-3-methyl-5-nitrobenzene 

Relevant articles and documents

Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy

Upon analysis of the reported crystal structure of PAK4 inhibitor KY04031 (PAK4 IC50?=?0.790?μM) in the active site of PAK4, we investigated the possibility of changing the triazine core of KY04031 to a quinazoline. Using KY04031 as a starting

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the conserved ATP binding site, designing selective CDK9 inhibitors has been challenging. Here we report our continued efforts in the optimization of 2,4,5-tri-substituted pyrimidine compounds as potent and selective CDK9 inhibitors. The most selective compound 30m was >100-fold selective for CDK9 over CDK1 and CDK2. These compounds showed broad anti-proliferative activities in various solid tumour cell lines and patient-derived chronic lymphocytic leukaemia (CLL) cells. Decreased phosphorylation of the carboxyl terminal domain (CTD) of RNAPII at Ser-2 and down-regulation of anti-apoptotic protein Mcl-1 were confirmed in both the ovarian cancer model A2780 and patient-derived CLL cells.

Halogenation Using Quaternary Ammonium Polyhalides. VI. Bromination of Aromatic Amines by Use of Benzyltrimethylammonium Tribromide

The reaction of aromatic amines with benzyltrimethylammonium tribromide in dichloromethane-methanol containing calcium carbonate powder for 0.5 h at room temperature gave bromo-substituted aromatic amines in good yields.