10219-00-8

Basic information

• Product Name: N-(4-fluorophenyl)-N,4-dimethylbenzenesulfonamide
• Synonyms: N-(4-fluorophenyl)-N,4-dimethylbenzenesulfonamide
• CAS NO: 10219-00-8
• Molecular Weight: 279.335
• Mol File: 10219-00-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-fluorophenyl)-N,4-dimethylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)-N,4-dimethylbenzenesulfonamide(10219-00-8)
• EPA Substance Registry System: N-(4-fluorophenyl)-N,4-dimethylbenzenesulfonamide(10219-00-8)

Safety Data

• Hazardous Substances Data: 10219-00-8(Hazardous Substances Data)

Upstream product

• 727-31-1 N-(4-fluorophenyl)-4-methylbenzenesulfonamide 
• 77-78-1 dimethyl sulfate 
• 599-62-2 N-methyl-N-phenyltoluenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-61-8 N-methylaniline 
• 625091-78-3 N-(2-bromo-4-fluorophenyl)-4-methylbenzenesulfonamide 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 364362-27-6 N-(2-bromo-4-fluoro-phenyl)-4,N-dimethyl-benzenesulfonamide 

Relevant articles and documents

Cu-Mediated C-H 18F-Fluorination of Electron-Rich (Hetero)arenes

This communication describes a method for the nucleophilic radiofluorination of electron-rich arenes. The reaction involves the initial C(sp2)-H functionalization of an electron-rich arene with MesI(OH)OTs to form a (mesityl)(aryl)iodonium salt

Synthetic use of 1,1,2,2-tetraphenyldisilane for the preparation of biaryls through the intramolecular free radical ipso-substitution of N-(2-bromoaryl)arenesulfonamides

Treatment of various N-methyl-N-(2-bromoaryl)arenesulfonamides (1a-g, 1i, and 1m) with 1,1,2,2-tetraphenyldisilane and AIBN under heating conditions gave the corresponding biaryl products (2a-g, 2i, and 2m) in moderate yields through the intramolecular radical ipso-substitution. However, N-H free N-(2-bromoaryl)arenesulfonamides 1h and 2-bromoaryl arenesulfonate 1j did not give the corresponding biarys. 1,1,2,2-Tetraphenyldisilane is the most effective reagent for 1,5-ipso-substitution on the sulfonamides among typical radical reagents such as diphenylsilane, tributyltin hydride, tris(trimethylsilyl)silane, and 1,1,2,2-tetraphenyldisilane. Furthermore, 1,1,2,2-tetraphenyldisilane has the advantages of low toxicity, stability, and ease of preparation.