1021926-24-8Relevant articles and documents
From COX-2 inhibitor nimesulide to potent anti-cancer agent: Synthesis, in vitro, in vivo and pharmacokinetic evaluation
Zhong, Bo,Cai, Xiaohan,Chennamaneni, Snigdha,Yi, Xin,Liu, Lili,Pink, John J.,Dowlati, Afshin,Xu, Yan,Zhou, Aimin,Su, Bin
, p. 432 - 444 (2012/02/14)
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. In the presented study, a series of ne
Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells
Su, Bin,Landini, Serena,Davis, Danyetta D.,Brueggemeier, Robert W.
, p. 1635 - 1644 (2007/10/03)
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. The enzyme is encoded by the CYP19 gene, which is expressed in a tissue-specific manner. Prostaglandin E2