1021945-07-2Relevant academic research and scientific papers
NAPHTHALENE DIIMIDE COMPOUNDS INTERACTING WITH G-QUADRUPLEX REGIONS IN DNA
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Page/Page column 20, (2009/07/03)
The invention relates to novel compounds which are naphthalene diimides of general formula (I). The compounds are used in therapy, particularly in cancer treatment.
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands
Cuenca, Francisco,Greciano, Olga,Gunaratnam, Mekala,Haider, Shozeb,Munnur, Deeksha,Nanjunda, Rupesh,Wilson, W. David,Neidle, Stephen
, p. 1668 - 1673 (2008/12/21)
A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.
