1022289-80-0

Basic information

• Product Name: N-(3-fluorobenzyl)benzenesulfonamide
• Synonyms: N-(3-fluorobenzyl)benzenesulfonamide
• CAS NO: 1022289-80-0
• Molecular Weight: 265.308
• Mol File: 1022289-80-0.mol

Chemical Properties

• CAS DataBase Reference: N-(3-fluorobenzyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluorobenzyl)benzenesulfonamide(1022289-80-0)
• EPA Substance Registry System: N-(3-fluorobenzyl)benzenesulfonamide(1022289-80-0)

Safety Data

• Hazardous Substances Data: 1022289-80-0(Hazardous Substances Data)

Upstream product

• 100-82-3 (3-fluorophenyl)methanamine 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Amide Iridium Complexes As Catalysts for Transfer Hydrogenation Reduction of N-sulfonylimine

Sulfonamide moieties widely exist in natural products, biologically active substance, and pharmaceuticals. Here, an efficient water-soluble amide iridium complexes-catalyzed transfer hydrogenation reduction of N-sulfonylimine is developed, which can be carried out under environmentally friendly conditions, affording a series of sulfonamide compounds in excellent yields (96-98%). In comparison with organic solvents, water is shown to be critical for a high catalytic transfer hydrogenation reduction in which the catalyst loading can be as low as 0.001 mol %. These amide iridium complexes are easy to synthesize, one structure of which was determined by single-crystal X-ray diffraction. This protocol gives an operationally simple, practical, and environmentally friendly strategy for synthesis of sulfonamide compounds.

Method for catalytic synthesis of N-benzyl benzene sulfonamide compounds by boric acid/oxalic acid catalytic system under microwave radiation

The invention discloses a method for catalytic synthesis of N-benzyl benzene sulfonamide compounds by a boric acid/oxalic acid catalytic system under microwave radiation. The method includes: adoptingbenzyl alcohol and derivatives thereof and benzene sulfonamide derivatives as raw materials, adopting the boric acid/oxalic acid system as a catalyst, and adopting fluorobenzene as a solvent; performing reaction in a microwave reactor under certain temperature and power conditions, performing vacuum concentration after reaction for a period of time, and subjecting a product to column chromatographic purification to realize efficient catalytic preparation of the N-benzyl benzene sulfonamide compounds. Compared with the prior art, the method has advantages of evidently higher reaction speed than that of conventional heating, mild reaction conditions, simplicity in operation, high yield, safety, low cost and environmental friendliness.

Solvent hydrogen bonding and structural effects on nucleophilic substitution reactions. Part-7: Reaction of benzenesulphonyl chloride with substituted benzylamines in acetonitrile/dimethylsulfoxide mixtures

Substitution reactions of eleven para- and meta-substituted benzylamines with benzenesulphonyl chloride in different mole fractions of dimethylsulfoxide (DMSO) in acetonitrile (AcN) have been investigated conductometrically. The second order rate constants found to increase with an increase in the mole fraction of DMSO up to 0.5 mole fraction and beyond that it remained nearly constant. Multiple correlation analysis of the rate data via Kamlet-Taft's solvatochromic parameters revealed that the solvent H-bonding and dipolarity/polarizability plays a dominant role in governing the reactivity and also solvent-solvent interaction influenced the preferential solvation and consequently the rate of the reaction. A curved Hammett plot was obtained and a mechanism was proposed to account for this nonlinear behaviour observed.