1022349-75-2Relevant academic research and scientific papers
Biomimetic asymmetric 1,3-dioplar cycloaddition: Amino acid precursors in biosynthesis serve as latent azomethine ylides
Guo, Chang,Song, Jin,Gong, Liu-Zhu
supporting information, p. 2676 - 2679 (2013/07/19)
The first asymmetric catalytic biomimetic three-component 1,3-dipolar cycloaddition of α-keto esters and benzylamine with electron-deficient olefins, inspired by the transamination of α-keto acids involving pyridoxal phosphate (PLP)-dependent enzymes in biological systems, giving several families of structurally diverse pyrrolidine derivatives in high yields and excellent enantioselectivities (up to 99% ee) under mild conditions is described.
Asymmetric organocatalytic three-component 1,3-dipolar cycloaddition: Control of stereochemistry via a chiral Bronsted acid activated dipole
Chen, Xiao-Hua,Zhang, Wen-Quan,Gong, Liu-Zhu
, p. 5652 - 5653 (2008/12/23)
A Bronsted acid catalyzed three-component asymmetric 1,3-dipolar addition reaction between aldehydes, amino esters, and dipolarophiles by a new bisphosphoric acid, derived from the linked BINOL, furnished multiply substituted pyrrolidines in high yield with excellent enantioselectivities under mild conditions. Copyright
