102238-33-5

Basic information

• Product Name: 1,5-dimethyl-2-phenyl-4-[(3-phenylprop-2-en-1-ylidene)amino]-1,2-dihydro-3H-pyrazol-3-one
• CAS NO: 102238-33-5
• Molecular Formula: C₂₀H₁₉N₃O
• Molecular Weight: 317.3844
• Mol File: 102238-33-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 466.1°C at 760 mmHg
• Flash Point: 235.7°C
• Density: 1.09g/cm³
• Vapor Pressure: 7.28E-09mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1,5-dimethyl-2-phenyl-4-[(3-phenylprop-2-en-1-ylidene)amino]-1,2-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dimethyl-2-phenyl-4-[(3-phenylprop-2-en-1-ylidene)amino]-1,2-dihydro-3H-pyrazol-3-one(102238-33-5)
• EPA Substance Registry System: 1,5-dimethyl-2-phenyl-4-[(3-phenylprop-2-en-1-ylidene)amino]-1,2-dihydro-3H-pyrazol-3-one(102238-33-5)

Safety Data

• Hazardous Substances Data: 102238-33-5(Hazardous Substances Data)

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 104-55-2 3-phenyl-propenal 
• 885-11-0 1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one 

Downstream Products

• 502762-17-6 1,2-dihydro-2,3-dimethyl-4-(4-oxo-2-styrylthiazolidin-3-yl)-1-phenylpyrazol-5-one 

Relevant articles and documents

DNA binding propensity and nuclease efficacy of biosensitive Schiff base complexes containing pyrazolone moiety: Synthesis and characterization

A series of novel Co(II), Cu(II), Ni(II) and Zn(II) complexes (1–8) were synthesized from pyrazolone precursor Schiff base(s), obtained by the condensation of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one (4–aminoantipyrine) with cinnamaldehyde/benzalde

Characterization of antimicrobial, antioxidant, and leishmanicidal activities of Schiff base derivatives of 4-aminoantipyrine

Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds

Synthesis and study of antibacterial activity of some Schiff bases derived from sulfonamide, 4-amino antipyrene and raceacetophenone

Schiff bases derived from sulfonamide, 4-amino antipyrene and raceacetophenone were screened for antibacterial activity against various clinical isolates (obtained from Urine, Blood, Tracheal secretion and Pus). Extracts of these compounds were evaluated on 5 pathogenic strains [E. coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae and Staphylococcus aureus]. The antibacterial activity was evaluated using the Agar Ditch method. The Schiff bases produced were (1) 4-[2-aza-2- (2-chlorophenyl) vinyl] benzene sulfonamide [AD1] (2) 4-[2-aza-2- (2-hydroxyphenyl) vinyl] benzene sulfonamide [AD2] (3) [1-aza-4-phenylbuta-1, 3-dienyl] benzene sulfonamide [AD3] (4) 4-[1-aza-2- (2chlorophenyl) vinyl]-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [AS1] (5) 4-[1-aza-2-(2-hydroxyphenyl) vinyl]-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [AS2] (6) 4-[1-aza-4-phenylbuta-1, 3-dienyl] 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [AS3] (7) 4-[2-aza-1-methyl-2- (2-nitro phenyl) vinyl]-6-ethylbenzene-1, 3-diol [ADS1] (8) 4-[2-aza-2(5-ehtyl-2, 4-dihydroxyphenyl) prop-1-enyl] benzene sulfonamide [ADS2]. The anti bacterial activity of these Schiff bases, were evaluated in one polar and one non polar (i.e., DMF and 1,4 dioxan) solvents. It is found that among AD and AS compounds AD compounds are better than AS and AD3 is the best while 1,4 dioxan solvent proved to be more effective than DMF. It appears that the sulfonamide moiety present with cinnamaldehyde side chain could be used as a lead molecule in drug designing (i.e. in inhibiting the above pathogenic bacteria).