102241-22-5Relevant academic research and scientific papers
Solvent-free Buchwald-Hartwig reaction of aryl and heteroaryl halides with secondary amines
Topchiy, Maxim A.,Asachenko, Andrey F.,Nechaev, Mikhail S.
, p. 3319 - 3322 (2014)
A highly efficient solvent-free protocol for the Buchwald-Hartwig amination of (hetero)aryl halides by secondary amines was developed. The reaction is mediated by a Pd(OAc)2/RuPhos catalytic system in air. Various (hetero)aryl halides were coupled with diaryl, alkyl-aryl, and dialkylamines in good to excellent yields (51 examples, 50-99% yield). Copyright
