102252-93-7

Upstream product

• 4023-81-8 1-(p-bromophenyl)-1,3-butanedione 
• 631-61-8 ammonium acetate 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 102253-00-9 5-(4-Bromo-benzoyl)-6-((E)-2-dimethylamino-vinyl)-1H-pyridin-2-one 
• 102267-47-0 5-(4-bromophenyl)-1,6-naphthyridin-2(1H)-one 
• 102252-92-6 5-(4-bromobenzoyl)-6-methyl-2(1H)-pyridinone 

Relevant academic research and scientific papers

Direct oxidative coupling of enamines and electron-deficient amines: TBAI/TBHP-mediated synthesis of substituted diaminoalkenes under metal-free conditions

A metal-free cross-coupling of enamines and electron-de fi cient amines through oxidative C(sp2)-N bond formation has been realized by using TBAI as catalyst and TBHP as oxidant. This novel strategy allows for an efficient organocatalytic synthesis of the synthetically useful diaminoalkene derivatives and is highlighted by appealing features such as readily available of the starting materials, wide substrate scope and transition-metal-free characteristics. (Chemical Equation Presented).

Metal-Free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines

A concise and efficient synthetic method for alkynyl quinolines through TfOH-promoted cascade 1,4-conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza-o-AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition-metal-free process features halogen groups tolerance, such as the ?Cl, ?Br, and ?I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.

Β-carbonyl enamines compound and as the application of the preparation of plant pathogenic bacteria antibacterial agent (by machine translation)

The invention relates to a β-carbonyl compound and enamines preparation of plant pathogenic bacteria as the application of an antimicrobial agent. Commercially available antibacterial agent Mijunzhi as a positive control, the linear growth of the mycelium determination process 23 kind of target compound anthrax pathogenicbacteria the apple, corn curved spore pathogenic bacterium, pathogenic bacteria rice blast fungus, reducing bakanae disease of wheat, such as watermelon blighting pathogenicbacteria 5 common inhibiting activity of plant pathogenic fungi, the result shows that: the target compound has tries the fungus inhibiting effect of different degree. Compound 8, 11, 12, 14, 16 of the activity is better, for the majority of their pathogenic bacteria testing EC 50 half of the effect of the concentration value is higher than the positive control drug kresoxim-methyl. Especially compound 8 inhibition of anthrax pathogenicbacteria the apple active (EC 50 = 2.15μg/mL) compound and 12 the inhibitory activity of pathogenic bacterium curved spore (EC 50 = 9.14μg/mL) are Mijunzhi active (EC 50 = 15.45 & 76.06μg/mL) of 8 times, has potential development and application values. (by machine translation)

A Facile and Novel Synthesis of 1,6-Naphthyridin-2(1H)-ones

A new and convenient procedure for the synthesis of 1,6-naphthyridin-2(1H)-ones and their derivatives is described.In the first scheme 5-acetyl-6--1,2-dihydro-2-oxo-3-pyridinecarbonitrile (4) obtained by the reaction of N,N-dimet