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Upstream product

• 25924-29-2 1-methyl-3a-(3,4-dimethoxyphenyl)-3,3a,4,5-tetrahydroindole-2,6(1H)-dione 
• 203245-01-6 N-methyl-2,2,2-trichloro-N-[2-(3,4-dimethoxyphenyl)-cyclohex-1-enyl]-acetamide 
• 5227-11-2 2-(3,4-dimethoxyphenyl)cyclohexanone 
• 203245-02-7 1-methyl-3-chloro-3a-(3,4-dimethoxyphenyl)-1,3,3a,4,5,6-hexahydro-indol-2-one 

Relevant academic research and scientific papers

β- and γ-lactams by nickel powder mediated 4-exo or 5-endo radical cyclisations. A concise construction of the mesembrine skeleton

N-Alkenyl trichloroacetamides, upon treatment with nickel powder and acetic acid in refluxing 2-propanol undergo reversible 4-exo radical cyclisation. The cyclised radical can be trapped in different ways leading to β-lactams. When the trap is omitted or not efficient enough, unusual irreversible 5-endo cyclisation occurs affording functionalised five-membered lactams. Synthesis of bicyclic γ-lactams has also been examined providing in few steps an access to the Sceletium alkaloids skeleton.

HEXAHYDROINDOLES AND TETRAHYDRO-1H-1-PYRINDINES: ALTERNATIVE FORMATION FROM 5-CARBOXAMIDOPENTANOIC ACIDS AND PROOF OF STRUCTURES

Under mild temperatures the 3-acetyl-3-aryl-5-carboxamidopentanoic acids 1 (Ar=phenyl or dimethoxyphenyl) easily undergo cyclisation in sulfuric acid or polyphosphoric acid (PPA) to the bicyclic lactamlactones 2.Surprisingly different lactams were obtaine