25924-29-2

Upstream product

• 280572-87-4 C₃₁H₄₇NO₅S₄ 
• 280572-85-2 8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-7-ene-7-carboxylic acid 
• 280572-86-3 8-(3,4-dimethoxy-phenyl)-7-isocyanato-1,4-dioxa-spiro[4.5]dec-7-ene 
• 168423-42-5 methyl 8-(((trifluoromethyl)sulfonyl)oxy)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 102277-68-9 3a-(3,4-dimethoxy-phenyl)-1-methyl-1,3,3a,4,5,6-hexahydro-indol-2-one 
• 21104-34-7 N-methyl-3a-<3,4-(dimethoxy)phenyl>-2,3,3a,4,5,6,7,7a-octahydroindole-2,6-dione 
• 6023-73-0 mesembrine 

Relevant academic research and scientific papers

[4 + 1] cycloaddition of bis(alkylthio)carbenes with vinyl isocyanates. Total synthesis of (±)-mesembrine

(matrix presented) The Sceletium alkaloid mesembrine has been synthesized in 13% overall yield by a sequence featuring a [4 + 1] cycloaddition of a bis-(alkylthio)carbene with a functionalized vinyl isocyanate.

HEXAHYDROINDOLES AND TETRAHYDRO-1H-1-PYRINDINES: ALTERNATIVE FORMATION FROM 5-CARBOXAMIDOPENTANOIC ACIDS AND PROOF OF STRUCTURES

Under mild temperatures the 3-acetyl-3-aryl-5-carboxamidopentanoic acids 1 (Ar=phenyl or dimethoxyphenyl) easily undergo cyclisation in sulfuric acid or polyphosphoric acid (PPA) to the bicyclic lactamlactones 2.Surprisingly different lactams were obtaine