1022903-96-3Relevant academic research and scientific papers
1-Arylaminoimidazole-2-thiones as intermediates in the synthesis of imidazo[2,1-b][1,3,4]thiadiazines
Neochoritis, Constantinos,Tsoleridis, Constantinos A.,Stephanidou-Stephanatou, Julia
, p. 3527 - 3533 (2008/09/21)
The synthesis of the hitherto unknown imidazo[2,1-b][1,3,4]thiadiazines 7 in good to very good yields (up to 77%) by using suitable imidazole-2-thione precursors 1 has been described, while S-vinylimidazoles 8 and 9 were isolated as by-products. Moreover, the reactivity of the three possible reaction sites of the starting thiones 1 was initially examined by methylation experiments, whereupon the enhanced reactivity of sulfur was proven by the isolation of the methylated derivatives 3 and 4. By prolonged methylation the imidazolinone 6 is finally formed. Theoretical calculations support the experimental results of alkylation products.
Direct synthetic approach to N-substituted 1-amino-2,3-dihydro-1H-imidazole-2-thiones
Schantl, Joachim G.,Lagoja, Irene M.
, p. 691 - 700 (2007/10/03)
In an efficient one-pot procedure, the title compounds (8) were obtained by the reaction of α-halo ketones (1) with potassium thiocyanate and monosubstituted hydrazines (3). The reaction is considered to proceed via the formation of azo-alkenes (5) and th
