191349-02-7

Upstream product

• 540-72-7 sodium thiocyanide 
• 4091-39-8 3-chloro-2-butanone 
• 100-63-0 phenylhydrazine 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 1022903-97-4 2-(methylthio)-N-phenyl-N,4,5-trimethyl-1H-imidazol-1-amine 
• 1022903-98-5 1,3-dihydro-1-((methyl)(phenyl)amino)-3,4,5-trimethyl-2H-imidazol-2-one 
• 1435872-15-3 2,3-dihydro-2-(tert-butylimino)-5,6-dimethyl-3-phenyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1435872-29-9 (2Z)-5-[[(1E,2E)-2-[2,2-bis(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-2-(tert-butylimino)-3-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-17-5 2-(benzyl)imino-2,3-dihydro-5,6-dimethyl-3-phenyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1435872-32-4 (2Z)-2-(benzylimino)-5-[[(1E,2E)-2-[2,2-bis(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-3-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-40-4 (2Z)-5-[[(1E,2E)-2-[2,2-bis(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-3-phenyl-2-(phenylimino)-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-13-1 2-cyclohexylimino-2,3-dihydro-5,6-dimethyl-3-phenyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1435872-27-7 (2Z)-5-[[(1E,2E)-2-[2,2-bis(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-2-(cyclohexylimino)-3-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-44-8 (2Z)-5-[[(1E,2E)-2-[2,2-bis[(1-methylethoxy)carbonyl]hydrazono]-1-methylpropylidene]amino]-2-(tert-butylimino)-3-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-42-6 (2Z)-5-[[(1E,2E)-2-[2,2-bis[(1-methylethoxy)carbonyl]hydrazono]-1-methylpropylidene]amino]-2-(cyclohexylimino)-3-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-50-6 (2Z)-2-(tert-butylimino)-5-[[(1E,2E)-2-[2-(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-3-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-11-9 1-[[(cyclohexylimino)methyl]phenylamino]-2,3-dihydro-4,5-dimethyl-2-thioxo-1H-imidazole 
• 1418010-64-6 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazol-2-yl)acetamide 

Relevant academic research and scientific papers

Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl) thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds.

Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N- (thiazole-2-yl)acetamide derivatives and their anticancer activities

In this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N- (thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with some 2-chloro-N-(thiazol-2-yl)acetamide compou

1-Arylaminoimidazole-2-thiones as intermediates in the synthesis of imidazo[2,1-b][1,3,4]thiadiazines

The synthesis of the hitherto unknown imidazo[2,1-b][1,3,4]thiadiazines 7 in good to very good yields (up to 77%) by using suitable imidazole-2-thione precursors 1 has been described, while S-vinylimidazoles 8 and 9 were isolated as by-products. Moreover, the reactivity of the three possible reaction sites of the starting thiones 1 was initially examined by methylation experiments, whereupon the enhanced reactivity of sulfur was proven by the isolation of the methylated derivatives 3 and 4. By prolonged methylation the imidazolinone 6 is finally formed. Theoretical calculations support the experimental results of alkylation products.

Direct synthetic approach to N-substituted 1-amino-2,3-dihydro-1H-imidazole-2-thiones

In an efficient one-pot procedure, the title compounds (8) were obtained by the reaction of α-halo ketones (1) with potassium thiocyanate and monosubstituted hydrazines (3). The reaction is considered to proceed via the formation of azo-alkenes (5) and th