102303-84-4

Upstream product

• 89-25-8 edaravone 
• 620-23-5 m-tolyl aldehyde 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1418030-49-5 6-(3-chlorophenyl)-4-methyl-2-phenyl-10-m-tolyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 
• 1418030-53-1 4-methyl-2-phenyl-6-m-tolyl-10-p-tolyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 
• 1453187-47-7 (4S,5S)-5-benzyl-3-methyl-1-phenyl-4-m-tolyl-4,5-dihydropyrano[2,3-c]pyrazol-6(1H)-one 
• 1569091-23-1 C₂₉H₂₆N₄O₂S 

Relevant academic research and scientific papers

Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones: Via dual α′,α′-C(sp3)-H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones

A bisphosphine-catalyzed sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones has been developed. Under the catalysis of DPPB [1,4-bis(diphenylphosphino)butane], the reaction proceeded smoothly to give spiro-[cyclopentanone] pyrazolone derivatives in moderate to good yields with good diastereoselectivities via sequential dual α′,α′-C(sp3)-H bifunctionalization annulation. This strategy provides a novel route toward the synthesis of spiro-[cyclopentanone] pyrazolones containing three contiguous stereocenters which possess potential pharmaceutical activities.

Organocatalytic Asymmetric Michael/Hemiketalization/Retro-aldol Reaction of α-Nitroketones with Unsaturated Pyrazolones: Synthesis of 3-Acyloxy Pyrazoles

An organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction between unsaturated pyrazolones and α-nitroketones is described. A bifunctional thiourea catalyst was found to be efficient for this reaction. With 10 mol % of catalyst, high yields as well as excellent enantioselectivities are attained for a variety of 3-acyloxy pyrazoles under mild reaction conditions.