1023625-72-0

Upstream product

• 90-02-8 salicylaldehyde 
• 57728-37-7 (R)-(+)-2-amino-1,1,3-triphenyl-1-propanol 
• 79868-78-3 (S)-(-)-2-amino-1,1,3-triphenyl-1-propanol 
• 100-58-3 phenylmagnesium bromide 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 63-91-2 L-phenylalanine 

Downstream Products

• 1453169-25-9 (S)-2-[(1-hydroxy-1,1,3-triphenylpropan-2-ylamino)methyl]phenol 

Relevant academic research and scientific papers

Synthesis of novel chiral tridentate schiff-base ligands and their applications in catalytic asymmetric henry reaction

A series of chiral tridentate Schiff-bases were prepared and used as ligands in the catalytic asymmetric Henry reaction. Under the optimal conditions, a variety of arylaldehydes were smoothly converted into corresponding adducts with high yields (up to 98

Catalytic intramolecular hydroamination of aminoallenes using titanium complexes of chiral, tridentate, dianionic imine-diol ligands

Alkylation of d- or l-phenylalanine or valine alkyl esters was carried out using methyl or phenyl Grignard reagents. Subsequent condensation with salicylaldehyde, 3,5-di-tert-butylsalicylaldehyde, or 5-fluorosalicylaldehyde formed tridentate, X2/sub

Asymmetric epoxidation of chalcones promoted by chiral schiff bases and amino alcohols

A series of chiral ligands were conveniently prepared from L-phenylalanine and characterized. Their application to the asymmetric epoxidation of chalcone was studied. The results demonstrated that 3a were efficient catalysts for enantioselective epoxidation of chalcone in moderate yield (up to 58.6%) and high enantioselectivities (up to 90% e.e.).

Synthesis of chiral secondary β-amino alcohols and their application in the asymmetric reduction of prochiral ketones

Nine chiral secondary β-amino alcohols were synthesized from chiral primary amino alcohols and aromatic aldehydes, and their catalysis for the asymmetric reduction of prochiral ketone was studied with good yields up to 87% ee (enantiometric excess).

New chiral molybdenum complex catalyzed sulfide oxidation with hydrogen peroxide

Six new cis-dioxomolybdenum(VI) complexes of chiral Schiff-base ligands, derived from condensation of various amino alcohols and substituted salicylaldehydes, have been prepared and characterized by NMR, IR, ESI-MS and single crystal X-ray diffraction techniques. The geometry around the molybdenum center is distorted octahedral in which a tridentate Schiff-base ligand with two anionic oxygens and one neutral imine nitrogen occupies meridional position. The octahedral geometry of the cis-dioxomolybdenum center is additionally completed by a coordinated labile solvent molecule. In some complexes the sixth site is found to be vacant where the relatively bulky substituents hinder the coordination of the solvent. These complexes are tested for catalytic enantioselective sulfoxidation reactions using hydrogen peroxide as oxidant at low temperature which shows high selectivity along with good to moderate enantiomeric excess. ESI-MS study of the reaction mixture indicates the formation of oxoperoxoMo(VI) complexes during catalysis. The steric effect originated from the substituent on chiral ligand on the catalytic reaction is also discussed. It is found that the substituents at the β position of the amino alcohol seem to greatly influence the enantioselectivity of the oxidation reactions.

Enantioselective nitroaldol (Henry) reaction catalyzed by chiral Schiff-base ligands

Chiral Schiff-bases 2, 3, 4 and 5 were designed for the enantioselective nitroaldol (Henry) reaction. The highest enantioselectivity was observed for ligand 4 (82% ee) when CH2Cl2 was used as a solvent.