57728-37-7Relevant academic research and scientific papers
Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions
Sato, Takafumi,Taylor, Lynne S.
, p. 5046 - 5053 (2015)
With the goal of better understanding how polymers inhibit crystallization in amorphous solid dispersions, crystal growth rates of the R and S enantiomers of a model chiral compound in the presence of chiral and achiral polymers were evaluated. The crystal growth rates of enantiomers in undercooled melts were inhibited to different extents by the same mass fraction of a chiral polymer, hydroxypropylmethyl cellulose acetate succinate. This is most likely due to differences in the ability of each enantiomer to form hydrogen bonding interactions with the polymer, which in turn impacts the crystallization behavior of the low molecular weight organic compound. In contrast, the achiral polymer polyvinylpyrrolidone, and the chiral polymer, hydroxypropylmethylcellulose phthalate showed the same inhibitory impact on each enantiomer.
Direct asymmetric N-specific reaction of nitrosobenzene with aldehydes catalyzed by a chiral primary amine-based organocatalyst
Qin, Long,Li, Lei,Yi, Lei,Da, Chao-Shan,Zhou, Yi-Feng
experimental part, p. 527 - 533 (2012/01/11)
Nitroso compounds have two reactive nitrogen and oxygen atoms. It is interesting and important to perform a nitrogen or oxygen selective reaction with interesting substrates. These atom specific reactions are crucial to specifically synthesis of specific compounds. An enantioselective N-specific reaction of nitrosobenzene with unmodified aldehydes was successfully achieved catalyzed first by a variety of primary amine-based organocatalysts with higher yield and enantioselectivity. The bulkier substituted groups of the organocatalyst and two hydrogen bonds from the organocatalyst and the oxygen atom of nitrosobenzene make the reaction preferentially N-specific and predominantly afford R products.
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
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Page/Page column 45-49; 64, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
Highly Diastereoselective Synthesis of trans-2,5-Disubstituted Tetrahydrofurans
Jalce, Gael,Seck, Matar,Franck, Xavier,Hocquemiller, Reynald,Figadere, Bruno
, p. 3240 - 3241 (2007/10/03)
trans-2,5-Disubstituted tetrahydrofurans were obtained as major diastereomers (trans / cis ratio 90:10-100: 0) when acetylated y-lactols derived from (S)-glutamic acid were treated with titanium enolates of N-acetyl (R)-oxazolidin-2-thiones. A simple tran
Synthesis and Antitumor Activity of Pt(II) Complexes of Benzyl-1,2-diaminoethane Ligands
Brunner, Henri,Hankofer, Peter,Treittinger, Barbara
, p. 1029 - 1038 (2007/10/02)
Twelve new diamine ligands are synthesized and characterized in which a benzyl group and another vicinal substituent or a benzyl group, a 4-Cl-benzyl group, and a 4-MeO-benzyl group, respectively, and two other geminal substituents are attached to the 1,2
