102368-24-1Relevant articles and documents
Improved conditions for the proline-catalyzed aldol reaction of acetone with aliphatic aldehydes
Martínez, Alberto,Zumbansen, Kristina,D?hring, Arno,Van Gemmeren, Manuel,List, Benjamin
supporting information, p. 932 - 934 (2014/05/06)
The proline-catalyzed asymmetric aldol reaction between aliphatic aldehydes and acetone has, to date, remained underdeveloped. Challenges in controlling this reaction include avoiding undesired side reactions such as aldol condensation and self-aldolization. In recent years we have developed optimized conditions, which enable high yields and good to excellent enantioselectivities, and which are presented in this communication. Georg Thieme Verlag Stuttgart New York.